After pursuing a degree in economics he started his career as a creative artist at an advertising agency. In 1994, his next film Unishe April released which won National Film Award for Best Feature Film.
Ghosh was a self-professed Satyajit Ray fan and inspired other filmmakers like Mithaq Kazimi who adapted Ghosh's film Raincoat in English.
In 1990, Rituparno got his first break in documentary film when his own agency, Tele-Response, a member of the Response family of companies, was commissioned to make a documentary on Vande Mataram for Doordarshan.
His second film, 'Unishe April', starring Aparna Sen, Debashree Roy, Prosenjit Chatterjee and Dipankar Dey, with a soundtrack composed by Jyotishka Dasgupta, was released in 1994, and won two National Film Awards in 1995, including Best Feature Film.
Before his career in film, Rituparno Ghosh worked at the Response India advertising agency and became known as an especially effective copywriter in Kolkata.
He was particularly noted for composing succinct, appealing one-liners and slogans for ad campaigns in Bengali during the 1980s.
The 2002 film 'Titli' was another narrative about a mother-daughter relationship—the teenage daughter has a crush on an older film star who, years ago, had an affair with the mother.
The film won National Film Award for Best Feature Film in Bengali.According to Sen, Ghosh's contribution to Indian cinema will be remembered forever.The independent film critic Saibal Chatterjee, in an article in The Hindu, described the way Ghosh mixed the literary traditions of Bengal with modern-day sensibility, thereby transcending the confines of region.He said in an interview in 2010— "There is much more to such relationships.Same-sex relationships, too, are extremely soulful, emotional and have the same pathos that any heterosexual relationship has." Bengali film director Mrinal Sen said that whenever he thought of direction, the name that came to mind was Rituparno Ghosh.
Among his noted ad campaigns were 'Sharad Samman' and 'Bongo Jiboner Ango' for the antiseptic ointment, Boroline, and others for Frooti, the largest-selling mango drink in India.